Khuzami was born in Brooklyn and grew up in Rochester, NY. In junior high she was inspired by Picasso’s portraits of women and was delighted to be able to express her teenage angst through painting. She studied art and filmmaking at SUNY New Paltz, then spent two years traveling throughout India, where she worked on a documentary film, and Japan, where she had the first one-woman show of her work. In the early 1980’s she moved back to New York City to pursue a career as an artist. While waiting tables and hoping to establish herself as a fine artist, Khuzami found a job painting the covers for Harlequin romance novels for the next four years. She was then hired to paint a mural, and by the 1990’s had established herself as a sought-after muralist. She was commissioned to paint murals all over America and Japan, from Tokyo Disneyland to the Capitol Building in Washington D.C. In 1996 she established her own successful mural-painting studio, and still receives commissions today. 

In the early 2000’s, after over two decades as a commercial and mural artist, Khuzami decided to venture back into the world of fine art. She found inspiration in the vintage kitsch objects she’d collected for many years, and began to paint them in surreal, satirical contexts, such as her works Bunny Bomb or Pinocchio and the Seven Deadly Sins. Her recent series Telenovela Suburbia creates an episodic narrative that uses toys and dollhouses to explore the dark corners of the human psyche. Khuzami has exhibited her paintings in many spaces, including the Leslie Lohman Museum, the Carter Burden Gallery, and SoHo Project Space. Most recently, her work was featured in a group show at the Jonathan LeVine Projects in Jersey City and in the 2022 SPRING/BREAK Art Show in New York City.